Tags: enhancer

Solubility Enhancement in Pharmaceutical Oral Solid and Parenteral Dosage Forms

Solubility Enhancement in Pharmaceutical Oral Solid and Parenteral Dosage Forms

Base Year: 2020
To be published: Q3 2021
Regional Coverage: Global

A comprehensive analysis examining the market for Solubility Enhancement in Pharmaceutical Oral Solid and Parenteral Dosage Forms globally.

The reports will focus on key trends, developments, changes, challenges, and business opportunities.

Scope

  • Consumption of solubility enhancement excipients in OSDF and parenteral dosage forms
  • Consumption of excipients by technology and methods used
  • Competitive landscape for the excipients for solubility enhancement
  • Technology and process analysis for solubility enhancement techniques
  • Detailed analysis of key drivers and restraints of the excipients consumption for solubility enhancement
  • Consumption forecast of excipients to 2030

Table of Contents

Introduction 

Executive Summary

An overview of the report findings plus forecast based on Kline’s Future View Forecasting Model

Introduction to Solubility Enhancement

  • Global pharmaceutical industry: overview
  • Regulatory scenario
  • Current situation of poorly bioavailable active

Solubility Enhancement Technologies

  • Overview of the technologies
  • Role of SE technologies in the oral solid and parenteral dosage forms
  • Advantages, disadvantages, and comparative assesment of the technologies
  • Commercial examples of technologies in the solubility enhancement market
  • Excipients used in the technologies
  • Upcoming technologies
  • Outlook

Comparative Assesment of SE technologies by dosage forms (OSDF versus parenteral)

  • Current situation and outlook

Solubility Enhancement Excipients

  • Introduction
  • Grades and prices
  • Consumption of excipient in the oral solid and parenteral dosage forms
  • Competitive Landscape
  • Commercial examples of drugs using excipient in solubility enhancement market
  • Novel/upcoming excipients for solubility enhancement
  • Outlook

Competitive Landscape

  • Introduction
  • Industry Structure
  • Supplier market share in the oral solid and parenteral dosage forms
  • Competitive Landscape
  • Short Profiles on major suppliers
  • Major drug delivery companies
  • Major customers

Comparative Assessment of SE excipients by dosage forms (OSDF versus parenteral)

  • Current consumption and outlook

Appraisal and Outlook

  • Major trends in oral solid parenteral dosage forms
  • Drivers and Restraints in solubility enhancement market
  • Outlook and forecast for the solubility enhancement market
Product Scope
Excipient Category Excipient type
Surfactants Cremophors
Polyethylene Glycols (PEG)

Polysorbates

Poloxamers

Solutol HS 15

Polyoxyl stearates

N-methyl-2-pyrrolidone

Ethanol

Glycerin

Lecithin

Docusate sodium (DSS)

Sodium lauryl sulfate (SLS)
Polymers Copovidone

HPMC

Polymethacrylates (PMAs)

HPMCAS

Povidone (PVP)

HPC

Polyvinyl

Caprolactam-polyvinyl acetate-polyethylene glycol copolymer

PEO

HPMCP
Lipid-based excipients (including water-insoluble surfactants)
Cyclodetrins
Mesoporous Silica
Dendrimers
Technology Scope
Technology Process
Particle

size reduction

 Micronization
Nanonization
Lipid Solubilization Several
Modification

of crystal habit

 Polymorphs
Pseudopolymorphs
Soild Dispersions Spray drying process
Hot-melt extrusion process
Complexation Complexation with cyclodextrins
Cryogenic techniques Lyophilization
Use of Liposomes and proliposomes
pH adjustment
Salt formation
Cosolvency
Hydrotopy
Coprocessed excipients
Use of Ion exchange resins
Solid Lipid Nanoparticles
Liquisolid Technology
Use of Silica
Use of Dendrimers

Report Benefits

This study will assist suppliers of pharmaceutical excipients in identifying opportunities within the global market of solubility enhancement. It will also serve as an invaluable tool in the strategic planning process:

  • Develop business strategies by understanding the trends and developments that are driving the global solubility enhancement excipients market
  • Identification of key growth areas by excipient type, application dosage form, and technologies of their use to enable development of targeted sales and marketing strategies
  • Forecasting scenarios from which to base solid strategic business plans
  • Competitive intelligence for use in benchmarking

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